CDX2, COX2 and MUC2 Expressions in Barrett's Esophagus: Can They Be Useful in Determination of the Dysplasia?
Author(s) -
İlknur Türkmen,
Nuray Başsüllü,
Süleyman Uraz,
Mehmet Ali Yerdel,
Reşat Memisoglu,
Gülen Doğusoy
Publication year - 2012
Publication title -
turkish journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.305
H-Index - 14
eISSN - 1309-5730
pISSN - 1018-5615
DOI - 10.5146/tjpath.2012.01132
Subject(s) - cdx2 , intestinal metaplasia , dysplasia , goblet cell , epithelium , esophagus , barrett's esophagus , metaplasia , pathology , immunohistochemistry , mucin 2 , columnar cell , adenocarcinoma , biology , medicine , cancer , gene expression , biochemistry , gene , homeobox
The description of Barrett's esophagus which is a risk factor for esophageal adenocarcinoma has differences, and the need of goblet cells for diagnosis is controversial. However, the pathophysiology in the metaplasia seen in Barrett's esophagus is not totally understood and new methods are searched for the assessment of progression to dysplasia. We aimed to search the immunohistochemical expression of CDX2, COX2 and MUC2 in Barrett's esophagus to detect any early evidence of intestinal metaplasia or dysplasia.
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