Immunhistochemical expression of galectin-3 in cancer: a review of the literature | Zendy

Tuğçe Çay | Zendy

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Immunhistochemical expression of galectin-3 in cancer: a review of the literature

Author(s) -

Tuğçe Çay

Publication year - 2011

Publication title -

turkish journal of pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.305

H-Index - 14

eISSN - 1309-5730

pISSN - 1018-5615

DOI - 10.5146/tjpath.2012.01090

Subject(s) - angiogenesis , galectin 3 , metastasis , carcinogenesis , galectin , biology , immunohistochemistry , immune system , pathology , lectin , cancer research , microbiology and biotechnology , cancer , immunology , medicine , genetics

Galectin-3 is a β-galactoside-binding animal lectin that containscarbohydrate-recognition domains and displays multiple related functions. It hasimportant roles in diverse biological events, such as embryogenesis, growth,cell adhesion, proliferation, differantiation, cell-cycle progression,apoptosis, mRNA splicing, and regulation of the immune system. Galectin-3 isexpressed in various cells and tissues, such as activated macrophages,eosinophils, neutrophils, mast cells, epithelium of the gastrointestinal andrespiratory tracts, kidneys and some sensory neurons, and is also involved intumorigenesis, angiogenesis, and tumor metastasis. In this review of theliterature, immunohistochemical Galectin-3 expression is investigated innumerous tumors and disorders of various organ systems.

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