Correlation of her 2/neu gene amplification with immunohistochemistry and other prognostic factors in breast carcinoma | Zendy

Saime Ramadan | Zendy; Özlem Yapıcıer | Zendy; Selçuk Kihtir | Zendy; Ayhan Erdemir | Zendy; T Doğan | Zendy; Ismail Uskent | Zendy; Haluk Onat | Zendy; Metin Çakmakçı | Zendy

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Correlation of her 2/neu gene amplification with immunohistochemistry and other prognostic factors in breast carcinoma

Author(s) -

Saime Ramadan,

Özlem Yapıcıer,

Selçuk Kihtir,

Ayhan Erdemir,

T Doğan,

Ismail Uskent,

Haluk Onat,

Metin Çakmakçı

Publication year - 2011

Publication title -

turkish journal of pathology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.305

H-Index - 14

eISSN - 1309-5730

pISSN - 1018-5615

DOI - 10.5146/tjpath.2011.01075

Subject(s) - immunohistochemistry , concordance , her2/neu , fluorescence in situ hybridization , progesterone receptor , breast carcinoma , in situ hybridization , estrogen receptor , breast cancer , hormone receptor , correlation , receptor , medicine , estrogen , in situ , pathology , oncology , biology , cancer , gene , gene expression , chemistry , genetics , geometry , mathematics , organic chemistry , chromosome

The purpose of this study was to determine relationship between HER-2/neu status and estrogen receptor, progesterone receptor, grade and age by comparing fluorescence in situ hybridization and immunohistochemistry. One hundred invasive breast carcinomas were reviewed and fluorescence in situ hybridization analysis was performed in all cases. Immunohistochemical scores showed a perfect concordance with fluorescence in situ hybridization amplification ratios (p < 0.0001). The results indicated a significant correlation between HER-2/neu and grade, but an inverse relationship between HER-2/neu and hormone receptors. In women aged ≤ 45 years, an inverse relationship between HER-2/neu and progesterone receptor was found and no association was noted between HER-2/neu and other factors. In women aged > 45 years, the results indicated a significant correlation between HER-2/neu and grade, and there was an inverse relationship between HER-2/neu and hormone receptors.

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