Papillary villoglandular carcinoma of cervix with multiple hpv genome

We report a case of well differentiated villoglandular adenocarcinoma with adenocarcinoma in situ component. Patient was an asymptomatic premenopausal woman, which was referred with atypical glandular cells of undetermined significance (AGUS) diagnosis established with cervicovaginal smear. Chromogenic in situ hybridization showed the presence of dual HPV (subtype 16/18 and 31/33) genomes. P53 overexpression and increased Ki 67 expression were detected on both invasive and in situ component. No evidence of disease was detected sixty-five months after staging laparotomy. This case is an uncommon example of multiple HPV infections leading to unusual cervical tumor.