A Case of a 63-bp Deletion in thempt64Gene ofMycobacterium tuberculosisStrains Which Showed False Negativity in the Immunochromatographic Assay | Zendy

Chang Eun Yoon | Zendy; Young Joon Hong | Zendy; Jin Kyung Lee | Zendy; Yoon Hwan Chang | Zendy; SeokIl Hong | Zendy

Open Access

A Case of a 63-bp Deletion in thempt64Gene ofMycobacterium tuberculosisStrains Which Showed False Negativity in the Immunochromatographic Assay

Author(s) -

Chang Eun Yoon,

Young Joon Hong,

Jin Kyung Lee,

Yoon Hwan Chang,

SeokIl Hong

Publication year - 2011

Publication title -

korean journal of clinical microbiology

Language(s) - English

Resource type - Journals

ISSN - 1229-0025

DOI - 10.5145/kjcm.2011.14.1.36

Subject(s) - mycobacterium tuberculosis complex , mycobacterium tuberculosis , tuberculosis , monoclonal antibody , negativity effect , gene , mycobacterium , microbiology and biotechnology , biology , antibody , virology , medicine , immunology , genetics , pathology , social psychology , psychology

Mycobacterium tuberculosis complex (MTBC) is discriminated from non-tuberculous mycobacteria (NTM) via an immunochromatographic assay (ICA) which is based on the reactions of monoclonal antibodies against MPT64, one of the predominant proteins excreted by MTBC. Recently, the authors of the present study discovered SD TB-negative Mycobacterium tuberculosis strains. In addition, sequence analysis of the mpt64 genes in these strains was performed and showed a deletion of 63 bp from nucleotides 196 to 258. In cases of MPT64-negative mycobacterium, the authors recommend performing TB PCR for correct diagnosis. (Korean J Clin Microbiol 2011;14:36-38)

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