Computational Investigation on Anti Cancer Compounds against Aldose Reductase as Anti Diabetic Agents | Zendy

Naresh Babu Muppalaneni | Zendy; Prof. Allam Appa Rao | Zendy

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Computational Investigation on Anti Cancer Compounds against Aldose Reductase as Anti Diabetic Agents

Author(s) -

Naresh Babu Muppalaneni,

Prof. Allam Appa Rao

Publication year - 2011

Publication title -

international journal of computer applications

Language(s) - English

Resource type - Journals

ISSN - 0975-8887

DOI - 10.5120/3795-5226

Subject(s) - aldose reductase , computer science , aldose reductase inhibitor , medicine , diabetes mellitus , endocrinology

has been carried out to find out the anti cancerous compounds can exhibit anti diabetic against aldose reductase. Diabetes and cancer are common diseases worldwide. In our study we have taken 17 anti cancerous compounds from inhouse chalcones database to perform docking studies. It reveals that there are some compounds which are binding with high affinity than the average docking score -126.048 kcal/mol of ligands of the 1AH3 protein. The anti cancer compounds exhibit high docking score than the average -126.048 kcal/mol. The anti cancer compound can be used as anti diabetic.

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