A Web based Database for Hypothetical Genes in the Human Genome

Due to accumulation of genomic data, the function of a vast amount of genes and the proteins encoded by them are unknown. Unless, the function of proteome encoded by the entire genome is not known, the biochemical processes and their importance cannot be understood. Also, the computational annotation returns a gene without any homolog in the protein database it encodes it as „hypothetical‟. Due to advancements in annotation projects, many genes whose evidence for expression invivo is not known and due to lack of similar protein could not be assigned function. This pose a challenge to functional genomics and automatic annotation of hypothetical genes are done at a faster rate using developed annotation tools to know the function of the hypothetical genes. Moreover, when the hypothetical genes are present in human, it is really a lacuna and hence functional annotation of the hypothetical genes in the human genome is the need of the hour. Hence, this work attempts to annotate the hypothetical genes in Human and makes the results publicly accessible using a web based database using PHP and MySQL.