VBM based MR Imaging Volumetric Analysis of AD and MCI

based morphometry is a method for detecting group differences in the density or volume of brain matter. The authors reviewed the literature on use of voxel-based morphometry in brain MRI imaging research to examine the capabilities of this method for clearly identifying specific differences in patients with MCI and AD (and compared with healthy subjects). A technique of segmenting human brain MRI image into total gray matter (GM) and total white matter (WM) - Voxel-based morphometry (VBM) was performed using VBM 5.1 toolbox and SPM5 in a Matlab environment. Images from (ADNI database) 15 AD and 15 MCI were used for investigation. The analysis revealed significant gray matter, white matter and CSF volume loss in the AD as compared with MCI patients. Quantitative analysis of %GM and %WM volumes can help in distinguishing atrophy of AD patterns from characteristics of the MCI.