Oral naltrexone to enhance analgesia in patients receiving continuous intrathecal morphine for chronic pain: A randomized, double-blind, prospective pilot study | Zendy

Scott R. Hamann | Zendy; Paul A. Sloan | Zendy

Open Access

Oral naltrexone to enhance analgesia in patients receiving continuous intrathecal morphine for chronic pain: A randomized, double-blind, prospective pilot study

Author(s) -

Scott R. Hamann,

Paul A. Sloan

Publication year - 2007

Publication title -

journal of opioid management

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.331

H-Index - 39

eISSN - 2375-0146

pISSN - 1551-7489

DOI - 10.5055/jom.2007.0051

Subject(s) - medicine , morphine , anesthesia , placebo , analgesic , naltrexone , randomized controlled trial , opioid , chronic pain , visual analogue scale , physical therapy , alternative medicine , receptor , pathology

Years' worth of observations suggest that morphine has both inhibitory and excitatory actions, and that selective blockade of excitatory effects by low doses of opioid antagonists (e.g., naltrexone) may paradoxically enhance morphine analgesia. The purpose of this pilot study was to evaluate and compare the analgesic efficacy and safety of two different low doses of oral naltrexone given in addition to chronic intrathecal morphine infusions in patients with chronic nonmalignant pain (CNMP).

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