English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. A 26-year-old man visited our hospital for the evaluation of leukopenia, an incidental finding during a routine health examination. His complete blood count values were as follows: leukocytes, 1.09×10 dry tap with unremarkable finding. On touch imprints, however, abnormal promyelocytes with multiple Auer rods, termed " faggot cells " , were observed in several fields (A, B; Wright staining, ×1,000), suggesting acute promyelocytic leukemia (APL). BM biopsy was hypercellular with diffuse infiltration of leukemic cells positive for myeloperoxidase. However, cytogenetic testing showed normal karyotype without t(15;17). Subsequently, reverse transcription-PCR using a re-aspirated specimen was performed, revealing the presence of the PML/RARA fusion transcript. No chromosomal abnormalities were found on cytogenetic examination of the re-aspirate specimen. Cases of APL lacking t(15;17) with complex variant rearrangements or submicroscopic insertion have been reported. The latter is considered as cryptic or masked t(15;17), occurring in approximately 5% of cases. The importance of adequate preparation and careful examination of BM touch imprints has been well described in the literature but may be overlooked at times.

Acute promyelocytic leukemia with normal karyotype initially diagnosed on bone marrow touch imprints