Open AccessThe Immunohistochemical Patterns of the β-Catenin Expression in Pilomatricoma
Author(s) -
Young Sik Kim,
Dong Hoon Shin,
Jong Soo Choi,
Ki Hong Kim
Publication year - 2010
Publication title -
annals of dermatology/annals of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 37
eISSN - 2005-3894
pISSN - 1013-9087
DOI - 10.5021/ad.2010.22.3.284
Subject(s) - pilomatricoma , immunohistochemistry , pathology , pilomatrixoma , cytoplasm , medicine , catenin , cell , beta catenin , microbiology and biotechnology , biology , wnt signaling pathway , signal transduction , genetics
Pilomatricoma is a benign follicular tumor that is composed of basaloid cells, transitional cells and shadow cells. beta-Catenin is a 92-kDa protein, and it plays important roles in cell-cell adhesion at the cell membrane and signal transduction in the nucleus. beta-Catenin has recently been shown to play an important role in the formation of hair follicle-related tumors, including pilomatricoma. However, the pattern and the intracellular localization of the beta-Catenin expression are still controversial.