Facile Synthesis of Mollugin by Kinetic Control and anti-HCV (Hepatitis C Virus) Activity of Its Analogues | Zendy

Da Hye Choi | Zendy; Na Ri Lee | Zendy; CheolGi Kim | Zendy; Jong Woo Kim | Zendy; Kyoungmin Lee | Zendy; JongGab Jun | Zendy

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Facile Synthesis of Mollugin by Kinetic Control and anti-HCV (Hepatitis C Virus) Activity of Its Analogues

Author(s) -

Da Hye Choi,

Na Ri Lee,

CheolGi Kim,

Jong Woo Kim,

Kyoungmin Lee,

JongGab Jun

Publication year - 2014

Publication title -

bulletin of the korean chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.237

H-Index - 59

eISSN - 1229-5949

pISSN - 0253-2964

DOI - 10.5012/bkcs.2014.35.11.3232

Subject(s) - hepatitis c virus , virology , chemistry , virus , combinatorial chemistry , medicine

Advanced Institutes of Convergence Technology, B&C Biopharm Co. Ltd., Suwon 443-270, KoreaReceived May 8, 2014, Accepted July 15, 2014Mollugin has been reported to have various biological activities including antineoplastic, antitumor, antiviralagainst the hepatitis B virus, anti-aging and antimutagenic activities. An effective and concise synthesis ofmollugin in two steps including kinetic control from the cheap starting material 1,4-naphthoquinone has beenintroduced, and mollugin derivatives thus prepared are screened for their inhibition ability against the hepatitisC virus (HCV) and the dihydrobenzochromene structure might be an additional anti-HCV agent as a newleading compound.Key Words : Mollugin, Hepatitis C virus, Rubiaceae, Kinetic control, DihydrobenzochromeneIntroductionMollugin 1a was isolated and characterized from the driedroot of Rubia cordifolia L. (Rubiaceae),

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