Ester Derivatives from Tannase-treated Prunioside A and Their Anti-inflammatory Activities | Zendy

ChangSoo Jun | Zendy; MyungJa Yoo | Zendy; WooYiel Lee | Zendy; KyungChell Kwak | Zendy; MoonSung Bae | Zendy; WooTaek Hwang | Zendy; DongHwan Son | Zendy; KyuYun Chai | Zendy

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Ester Derivatives from Tannase-treated Prunioside A and Their Anti-inflammatory Activities

Author(s) -

ChangSoo Jun,

MyungJa Yoo,

WooYiel Lee,

KyungChell Kwak,

MoonSung Bae,

WooTaek Hwang,

DongHwan Son,

KyuYun Chai

Publication year - 2007

Publication title -

bulletin of the korean chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.237

H-Index - 59

eISSN - 1229-5949

pISSN - 0253-2964

DOI - 10.5012/bkcs.2007.28.1.073

Subject(s) - chemistry , hydrolysis , esterase , monoterpene , lipopolysaccharide , tannase , anti inflammatory , methanol , biochemistry , organic chemistry , enzyme , antioxidant , pharmacology , biology , gallic acid , endocrinology

Prunioside A, isolated from the methanol extract of Spiraea prunifolia var. Simpliciflora's root, is composed of coumaroyl, monoterpene-type, and glucosyl units. The esterase activity of tannase was used to remove the p-coumaroyl and glucopyranosyl groups. The enzymatically hydrolyzed compound was reacted with various acyl chlorides to synthesize its ester derivatives, which showed the inhibitory effects on NO production in murine machrophage?like RAW 264.7 cells stimulated with lipopolysaccharide and interferon-γ.

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