Open AccessIndium Mediated Barbier Reaction of Ninhydrin and Isatin
Author(s) -
Ji-Hyeon Lee Gong
Publication year - 2003
Publication title -
bulletin of the korean chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.237
H-Index - 59
eISSN - 1229-5949
pISSN - 0253-2964
DOI - 10.5012/bkcs.2003.24.4.507
Subject(s) - ninhydrin , isatin , indium , chemistry , organic chemistry , combinatorial chemistry , biochemistry , amino acid
Thus, we intended to examine systematically on theindium mediated Barbier reaction of ninhydrin and isatinwith allyl bromide, methallyl bromide and benzyl bromide.The reaction of ninhydrin (1) and benzyl bromide occurredat the 2-position of ninhydrin selectively to give 2a in 39%yield. We used typical experimental conditions for theindium-mediated Barbier reactions: Use of indium metal inthe presence of sodium iodide in N,N-dimethylformamide.
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