Interleukin-10 Serum Levels after Vaccination with In Vivo Prepared Toxoplasma gondii Excreted/Secreted Antigens | Zendy

Seyed Hossein Abdollahi | Zendy; Fateme Ayoobi | Zendy; Hossein Khorramdelazad | Zendy; Gholamhossein Hassanshahi | Zendy; Behzad Nasiri Ahmadabadi | Zendy; Mohammad Taghi Rezayati | Zendy; Ali Ravary | Zendy; Ali Shamsizadeh | Zendy; Mohammad Kazemi Arababadi | Zendy

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Interleukin-10 Serum Levels after Vaccination with In Vivo Prepared Toxoplasma gondii Excreted/Secreted Antigens

Author(s) -

Seyed Hossein Abdollahi,

Fateme Ayoobi,

Hossein Khorramdelazad,

Gholamhossein Hassanshahi,

Behzad Nasiri Ahmadabadi,

Mohammad Taghi Rezayati,

Ali Ravary,

Ali Shamsizadeh,

Mohammad Kazemi Arababadi

Publication year - 2013

Publication title -

oman medical journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.395

H-Index - 31

eISSN - 2070-5204

pISSN - 1999-768X

DOI - 10.5001/omj.2013.29

Subject(s) - toxoplasma gondii , vaccination , toxoplasmosis , antigen , immune system , immunology , medicine , in vivo , adjuvant , virology , antibody , microbiology and biotechnology , biology

Toxoplasma gondii is a worldwide prevalent zoonotic parasite which causes toxoplasmosis. An appropriate vaccine for animals could interrupt the circle between animals and humans. Our previous study showed that excreted/secreted antigens (E/SA), derived from the peritoneum of mice infected with T. gondii tachyzoites could be considered as a good candidate for animal vaccination. Interleukin-10 (IL-10) inhibits proliferation of B and T lymphocytes and induces homeostasis in immune system responses. However, since IL-10 has also been shown to suppress the killing of T. gondii by human macrophages, the aim of this study was to evaluate IL-10 serum levels after vaccination with T. gondii E/SA prepared in vivo.

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