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Have We Found the Panacea to Covid-19 with Remdesivir, An Old but Newly Packaged Drug?
Author(s) -
Abdul Malik Mohamed Thalha,
Yeong Yeh Lee,
Alwi Muhd Besari,
Sharifah Faridah Syed Omar
Publication year - 2020
Publication title -
the journal of the royal college of physicians of edinburgh
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.275
H-Index - 26
eISSN - 2042-8189
pISSN - 1478-2715
DOI - 10.4997/jrcpe.2020.217
Subject(s) - panacea (medicine) , covid-19 , drug , drug repositioning , virology , medicine , pharmacology , infectious disease (medical specialty) , outbreak , alternative medicine , disease , pathology
Investigators provided open-label remdesivir on a compassionate-use basis to patients hospitalised with severe COVID-19, an illness caused by infection with SARSCoV-2. Severity was defi ned as an oxygen saturation of 94% or less while patients were breathing ambient air or receiving oxygen support. Patients with contraindications for remdesivir, including creatinine clearance below 30 ml/min and elevated liver enzymes beyond fi ve times upper limit of normal, were excluded. Patients received a 10-day course of intravenous remdesivir, starting with loading dose of 200 mg administered intravenously on day one, followed by 100 mg daily for the remaining nine days.

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