Comparison of Clinical Utility between Phadiatop Assay and AdvanSureTM AlloScreen

eISSN 2093-6338 diseases are caused by hypersensitivity of the immune system to typically harmless substances in the environment. The underlying mechanism involves the binding of immunoglobulin E antibody (IgE) to an allergen and then to mast cells or basophil receptors, where it triggers the release of in ammatory cytokines, such as histamine [2]. Allergy has various manifestations, ranging from mild symptoms, such as red eye and pruritus, to anaphylaxis, which can lead to death [3]. It is important to identify the culprit allergen a patient is sensitized to, as sensitization varies between patients and allergen avoidance is the best treatment. Allergy screenings and diagnoses are commonly conducted using the skin-prick test (SPT) and allergen-speci c IgE (sIgE) tests [4, 5]. SPT is the most common method for con rming the IgE-mediated underlying mechanism of allergic diseases, as it is easy to perform, sensitive, cost-effective, and provides prompt results [6]. However, SPT has several limitations, such as its qualitative-only INTRODUCTION