Serum beta-glucuronidase levels in children with leprosy | Zendy

Devki Nandan | Zendy; K Venkatesan | Zendy; Kiran Katoch | Zendy; Rajeshwar Dayal | Zendy

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Serum beta-glucuronidase levels in children with leprosy

Author(s) -

Devki Nandan,

K Venkatesan,

Kiran Katoch,

Rajeshwar Dayal

Publication year - 2007

Publication title -

leprosy review

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 43

eISSN - 2162-8807

pISSN - 0305-7518

DOI - 10.47276/lr.78.3.243

Subject(s) - leprosy , medicine , pathogenesis , glucuronidase , beta (programming language) , immunology , beta glucuronidase , regimen , enzyme , lepromatous leprosy , biology , biochemistry , gene expression , computer science , gene , programming language

A study was undertaken to find out the usefulness of determining the circulating levels of beta-glucuronidase, a lysosomal enzyme in leprosy affected children of less than 15 years of age. The serum enzyme levels were significantly higher in BB/BL patients compared to healthy control children as well as children with skin diseases other than leprosy. Treatment with Multidrug regimen advocated by WHO for multi/paucibacillary leprosy resulted in a significant fall in the serum enzyme levels in BB and BL cases. The findings suggest that serum beta-glucuronidase may be a useful parameter for the activity and extent of pathogenesis in leprosy.

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