C. Phyllacanthus antioxidant & protective activity in albino wister rats

In this present study I have selected a plant, which has shown good hepato protective as well as antioxidant properties.  Undoubtedly  ,  the  plant  kingdom still hold many species of plant containing substances of medicinal value, which have yet to be  discovered  ; large  numbers of plants are constantly  being screened for  their  possible  pharmacological  value  particularly   for   their   hepato protective  properties. A large number of plants and formulations have been claimed to have hepato protective activity. Nearly 160 phyto constituents from 101 plants belonging to 55 families have been claimed to possess liver protecting activity. In India, more than 87 plants are used in 33 patented and proprietary multi-ingredient plant formulations.The ability of EECP to enhance the levels of antioxidants along with its anti lipid per oxidative activity suggests that this compound might be potentially useful in counteracting free-radical-mediated tissue damage caused by hepato toxicity. Studies on the antioxidative potency of various flavonoids have confirmed the importance of the distribution and quantity of the hydroxyl groups. In general, the antioxidative properties of polyphenols depend on hydroxylation of ring B. The present results corroborate the protective action of EECP in D- galactosamine intoxication of rats, particularly noticeable with the high dose used by us (400 mg/kg body weight). Supplementation with this flavonoid ameliorated the hepato protective and antioxidant activity in D-galactosamine-induced hepatitis in rats.