Outcome of Clostridioides difficile infections treated in a Swiss tertiary care hospital: an observational study | Zendy

Sebastian Haubitz | Zendy; Nicole Bartlom | Zendy; Evelin Bucheli Laffer | Zendy; Constanze Spelters | Zendy; Hans Fankhauser | Zendy; Christoph Andreas Fux | Zendy

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Outcome of Clostridioides difficile infections treated in a Swiss tertiary care hospital: an observational study

Author(s) -

Sebastian Haubitz,

Nicole Bartlom,

Evelin Bucheli Laffer,

Constanze Spelters,

Hans Fankhauser,

Christoph Andreas Fux

Publication year - 2020

Publication title -

schweizerische medizinische wochenschrift

Language(s) - English

Resource type - Journals

ISSN - 0036-7672

DOI - 10.4414/smw.2020.20173

Subject(s) - medicine , metronidazole , interquartile range , epidemiology , retrospective cohort study , mortality rate , antibiotics , surgery , microbiology and biotechnology , biology

The high 60-day mortality suggests that CDI is a strong indicator of frailty. Metronidazole was associated with low recurrence rates at minimal costs in patients with uncomplicated CDI, but had relevant shortcomings in patients with severe CDI and/or a high risk of recurrence, suggesting that these vulnerable patients might better be treated with oral vancomycin and fidaxomicin, according to the latest guidelines. .

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