Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus | Zendy

Mehmet Zahid Koçak | Zendy; Gülali Aktaş | Zendy; Edip Erkuş | Zendy; Özgür Mehmet Yis | Zendy; Tuba Taslamacıoğlu Duman | Zendy; Burçin Meryem Atak Tel | Zendy; Haluk Şavlı | Zendy

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Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus

Author(s) -

Mehmet Zahid Koçak,

Gülali Aktaş,

Edip Erkuş,

Özgür Mehmet Yis,

Tuba Taslamacıoğlu Duman,

Burçin Meryem Atak Tel,

Haluk Şavlı

Publication year - 2019

Publication title -

schweizerische medizinische wochenschrift

Language(s) - English

Resource type - Journals

ISSN - 0036-7672

DOI - 10.4414/smw.2019.20139

Subject(s) - medicine , neuregulin 1 , neuregulin , type 2 diabetes mellitus , odds ratio , endocrinology , confidence interval , diabetes mellitus , receptor

Neuregulin-4 is significantly increased in patients with T2DM compared with control subjects, which means that it could be a marker of T2DM. Since neuregulin-4 was correlated with fasting glucose, we suggest that elevated neuregulin-4 could predict poor control in T2DM for short periods when HbA1c is not useful. Moreover, one unit elevation in neuregulin-4 (0.1 ng/ml) increases the rate of existence of T2DM 4.4-fold, independently from other variables.

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