Chronic rhinosinusitis in unified airway disease: surfactant proteins as mediators of respiratory immunity | Zendy

George T. Noutsios | Zendy; Saurabh Sharma | Zendy

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Chronic rhinosinusitis in unified airway disease: surfactant proteins as mediators of respiratory immunity

Author(s) -

George T. Noutsios,

Saurabh Sharma

Publication year - 2019

Publication title -

schweizerische medizinische wochenschrift

Language(s) - English

Resource type - Journals

ISSN - 0036-7672

DOI - 10.4414/smw.2019.20104

Subject(s) - medicine , immunology , context (archaeology) , asthma , innate immune system , cystic fibrosis , copd , airway , respiratory system , immunity , disease , respiratory disease , chronic rhinosinusitis , sinusitis , immune system , lung , pathology , paleontology , biology , surgery

CRS and asthma coexist and are interconnected. Therefore, management of CRS and asthma must be jointly carried out as one functional entity. SP-A and SP-D bridge the innate and adaptive immunity mechanisms of the sinonasal epithelium to bring together a well-orchestrated mechanism that effectively fights pathogens. The use of SP-A to ameliorate the innate immune responses in CRS is a new concept and is likely to lead to new horizons in CRS therapeutic regimens. .

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