The sensitivity and specificity of the mannitol bronchial challenge test to identify asthma in different populations: a systematic review | Zendy

Philipp Kernen | Zendy; Esther Helen Steveling | Zendy; Ramon Saccilotto | Zendy; Heike Raatz | Zendy; Matthias Briel | Zendy; Michael Koller | Zendy; Marie Westwood | Zendy; Heiner C. Bucher | Zendy; David Miedinger | Zendy; Jrg Leuppi | Zendy

Open Access

The sensitivity and specificity of the mannitol bronchial challenge test to identify asthma in different populations: a systematic review

Author(s) -

Philipp Kernen,

Esther Helen Steveling,

Ramon Saccilotto,

Heike Raatz,

Matthias Briel,

Michael Koller,

Marie Westwood,

Heiner C. Bucher,

David Miedinger,

Jrg Leuppi

Publication year - 2019

Publication title -

schweizerische medizinische wochenschrift

Language(s) - English

Resource type - Journals

ISSN - 0036-7672

DOI - 10.4414/smw.2019.20100

Subject(s) - medicine , asthma , provocation test , bronchial hyperresponsiveness , mannitol , test (biology) , immunology , pathology , respiratory disease , alternative medicine , chemistry , organic chemistry , lung , paleontology , biology

Studies on the accuracy of the mannitol test were heterogeneous. Overall specificity was higher than sensitivity and therefore the mannitol test seems to be a suitable diagnostic tool to confirm asthma. However, the high level of heterogeneity among the included studies makes a conclusive statement on the accuracy of the mannitol test difficult and further research is needed. As bronchial provocation tests can be especially useful in patients with an intermediate probability of asthma diagnosis, further studies are needed that include subjects with asthma symptoms but intermediate probability of asthma diagnosis.

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