Regulatory T cells: balancing protection versus pathology | Zendy

Nikolas Rakebrandt | Zendy; Katharina Littringer | Zendy; Nicole Joller | Zendy

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Regulatory T cells: balancing protection versus pathology

Author(s) -

Nikolas Rakebrandt,

Katharina Littringer,

Nicole Joller

Publication year - 2016

Publication title -

schweizerische medizinische wochenschrift

Language(s) - English

Resource type - Journals

ISSN - 0036-7672

DOI - 10.4414/smw.2016.14343

Subject(s) - autoimmunity , foxp3 , medicine , immunology , immune system , context (archaeology) , effector , disease , immunity , cancer , inflammation , pathogenesis , immune tolerance , regulatory t cell , t cell , biology , il 2 receptor , pathology , paleontology

Foxp3 + regulatory T cells (Tregs) maintain immune tolerance, prevent autoimmunity and modulate immune responses during infection and cancer. Recent studies have revealed considerable heterogeneity and plasticity within the Treg compartment, depending on the immunological context, which may result in Tregs losing their suppressive function in inflammatory environments. We review how dysfunctional Tregs contribute to disease pathogenesis in inflammatory conditions and how inappropriate regulatory responses may hamper protective immunity in the context of infection and cancer. We also discuss how Tregs might be targeted therapeutically to re-establish a proper balance between regulatory and effector responses in autoimmunity, infections, and cancer

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