Daptomycin for highly resistant Enterococcus faecium infection | Zendy

Christiane Rosin | Zendy; Christine Bernsmeier | Zendy; JM Entenza | Zendy; P. Moreillon | Zendy; Reno Frei | Zendy; Maja Weisser | Zendy; Ursula Flückiger | Zendy

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Daptomycin for highly resistant Enterococcus faecium infection

Author(s) -

Christiane Rosin,

Christine Bernsmeier,

JM Entenza,

P. Moreillon,

Reno Frei,

Maja Weisser,

Ursula Flückiger

Publication year - 2012

Publication title -

schweizerische medizinische wochenschrift

Language(s) - English

Resource type - Journals

ISSN - 0036-7672

DOI - 10.4414/smw.2012.13603

Subject(s) - daptomycin , enterococcus faecium , medicine , lipopeptide , microbiology and biotechnology , staphylococcus aureus , antibiotics , vancomycin , enterococcus , bacteria , biology , genetics

We report a case series of 11 patients with severe E. faecium infections treated with daptomycin. All strains were resistant to ampicillin (MIC >8 mg/l), but susceptible to vancomycin. Seven out of 11 strains were also highly resistant to gentamicin (MIC >500 mg/l). All patients were treated with multiple broad-spectrum antibiotics prior to isolation of E. faecium and had severe underlying diseases. Our experience suggests that salvage therapy with daptomycin might be a safe and efficacious treatment for E. faecium infections.

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