The emerging role of serotonin in liver regeneration | Zendy

GK Papadimas | Zendy; K.N. Tzirogiannis | Zendy; MG Mykoniatis | Zendy; AD Grypioti | Zendy; GA Manta | Zendy; Georgios I. Panoutsopoulos | Zendy

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The emerging role of serotonin in liver regeneration

Author(s) -

GK Papadimas,

K.N. Tzirogiannis,

MG Mykoniatis,

AD Grypioti,

GA Manta,

Georgios I. Panoutsopoulos

Publication year - 2012

Publication title -

schweizerische medizinische wochenschrift

Language(s) - English

Resource type - Journals

ISSN - 0036-7672

DOI - 10.4414/smw.2012.13548

Subject(s) - serotonin , enterochromaffin cell , medicine , liver regeneration , neurotransmitter , 5 ht receptor , gastrointestinal tract , regeneration (biology) , paracrine signalling , platelet , receptor , endocrinology , microbiology and biotechnology , biology

Serotonin has a multifunctional role in many different organs serving either as a neurotransmitter in the central nervous system or a paracrine factor in the gastrointestinal tract. Over 90% of serotonin is synthesised in the enterochromaffin cells of the intestine and subsequently taken up by platelets. The involvement of platelet-derived serotonin in liver mass restoration after partial hepatectomy or toxic injury has been greatly investigated during the last decade. There is a growing body of evidence implicating serotonin in hepatic regeneration through altered expression of serotonin receptor subtypes in the liver. This review article provides a brief overview on the current knowledge about the actions of serotonin in liver regeneration.

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