Open AccessDistribution of the functional MDR1 C3435T polymorphism in the Han population of China
Author(s) -
Yanhong Li,
Yonghua Wang,
Jie Sun,
Yan Li,
Ling Yang
Publication year - 2006
Publication title -
schweizerische medizinische wochenschrift
Language(s) - English
Resource type - Journals
ISSN - 0036-7672
DOI - 10.4414/smw.2006.11113
Subject(s) - genotype , single nucleotide polymorphism , snp , allele , genetics , polymorphism (computer science) , allele frequency , han chinese , medicine , population , china , restriction fragment length polymorphism , genotype frequency , exon , traditional medicine , biology , gene , geography , environmental health , archaeology
3435C>T, a single nucleotide polymorphism (SNP) in exon 26 of the MDR1 gene, is linked to the variability of P-gp expression and function among different individuals. It was found that ethnic differences exist in the polymorphism of the MDR1(C3435T) gene. However, the distribution of 3435C>T genotypes in the Chinese Han population is not clear up till now.
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