Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice | Zendy

Stéphane Cook | Zendy; Olivier Hügli | Zendy; Marc Egli | Zendy; Péter Vollenweider | Zendy; Rémy Burcelin | Zendy; Pascal Nicod | Zendy; Bernard Thorens | Zendy; Urs Scherrer | Zendy

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Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice

Author(s) -

Stéphane Cook,

Olivier Hügli,

Marc Egli,

Péter Vollenweider,

Rémy Burcelin,

Pascal Nicod,

Bernard Thorens,

Urs Scherrer

Publication year - 2003

Publication title -

schweizerische medizinische wochenschrift

Language(s) - English

Resource type - Journals

ISSN - 0036-7672

DOI - 10.4414/smw.2003.10239

Subject(s) - medicine , endocrinology , enos , metabolic syndrome , insulin resistance , leptin , uric acid , insulin tolerance test , insulin , triglyceride , impaired glucose tolerance , nitric oxide , diabetes mellitus , cholesterol , nitric oxide synthase , obesity , insulin sensitivity

The metabolic syndrome comprises a clustering of cardiovascular risk factors but the underlying mechanism is not known. Mice with targeted disruption of endothelial nitric oxide synthase (eNOS) are hypertensive and insulin resistant. We wondered, whether eNOS deficiency in mice is associated with a phenotype mimicking the human metabolic syndrome.

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