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Impaired sensorimotor gating in schizophrenia with deficit and with nondeficit syndrome
Author(s) -
Katja Ludewig,
Franz X. Vollenweider
Publication year - 2002
Publication title -
schweizerische medizinische wochenschrift
Language(s) - English
Resource type - Journals
ISSN - 0036-7672
DOI - 10.4414/smw.2002.09873
Subject(s) - prepulse inhibition , moro reflex , schizophrenia (object oriented programming) , acoustic startle reflex , startle response , medicine , psychosis , sensory gating , psychology , startle reaction , audiology , gating , reflex , neuroscience , psychiatry
Prepulse inhibition (PPI) is the normal suppression of the startle reflex when the intense startling stimulus is preceded by a barely detectable prepulse. PPI has been proposed to reflect a measure of sensorimotor gating or filtering. Deficits in PPI has been found in schizophrenia in various prepulse conditions. The aim of this study was to investigate whether deficits in particular prepulse conditions relate to psychopathological syndromes.

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