Distinct endobronchial expression of matrix-metalloproteinases (MMP) and their endogenous inhibitors in lung cancer | Zendy

Frank Reichenberger | Zendy; Oliver Eickelberg | Zendy; C Wyser | Zendy; André P. Perruchoud | Zendy; Michael Roth | Zendy; Miriam Tamm | Zendy

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Distinct endobronchial expression of matrix-metalloproteinases (MMP) and their endogenous inhibitors in lung cancer

Author(s) -

Frank Reichenberger,

Oliver Eickelberg,

C Wyser,

André P. Perruchoud,

Michael Roth,

Miriam Tamm

Publication year - 2001

Publication title -

schweizerische medizinische wochenschrift

Language(s) - English

Resource type - Journals

ISSN - 0036-7672

DOI - 10.4414/smw.2001.09652

Subject(s) - matrix metalloproteinase , adenocarcinoma , pathology , medicine , metastasis , extracellular matrix , zymography , lung cancer , adenocarcinoma of the lung , lung , carcinoma , basement membrane , immunohistochemistry , cancer research , cancer , biology , microbiology and biotechnology

Degradation of extracellular matrix (ECM) and basement membranes is required for tumour cell invasion and metastasis. The ECM is degraded by matrix metalloproteinases (MMP) which are counteracted by tissue inhibitors of metalloproteinases (TIMP). In aggressive tumours the balance of proteolysis and antiproteolysis is disrupted, resulting in fast tumour progression and invasiveness. We examined MMP and TIMP expression patterns in bronchial washings of 58 consecutive lung tumour patients and 10 controls. Pathohistological investigations revealed squamous cell carcinoma (n = 23), adenocarcinoma (n = 18), small cell lung carcinoma (n = 9), and pulmonary metastases of extrapulmonary tumours (n = 8). MMP/TIMP expression was correlated to histology, location, or staging of tumours.

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