Tetrahydrobiopterin enhances myocardial blood flow in healthy volunteers: a double-blind placebo controlled study | Zendy

Roland B. Walter | Zendy; Philipp A. Kaufmann | Zendy; Andreas K. Buck | Zendy; Thomas Berthold | Zendy; C. Wyss | Zendy; Gustav K. von Schulthess | Zendy; Andreas Schaffner | Zendy; Gabriele Schoedon | Zendy

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Tetrahydrobiopterin enhances myocardial blood flow in healthy volunteers: a double-blind placebo controlled study

Author(s) -

Roland B. Walter,

Philipp A. Kaufmann,

Andreas K. Buck,

Thomas Berthold,

C. Wyss,

Gustav K. von Schulthess,

Andreas Schaffner,

Gabriele Schoedon

Publication year - 2001

Publication title -

schweizerische medizinische wochenschrift

Language(s) - English

Resource type - Journals

ISSN - 0036-7672

DOI - 10.4414/smw.2001.06147

Subject(s) - tetrahydrobiopterin , medicine , placebo , in vivo , blood flow , vasodilation , nitric oxide , hemodynamics , nitric oxide synthase , anesthesia , pharmacology , endocrinology , pathology , alternative medicine , microbiology and biotechnology , biology

Tetrahydrobiopterin (BH4) is a regulatory cofactor for the activity of nitric oxide synthases. Vasodilating properties of BH4 have been reported in vitro and in vivo. The influence of BH4 on myocardial blood flow (MBF), however, is largely unknown. We therefore performed a double-blind, placebo-controlled study to investigate the effect of intravenous BH4 on MBF in healthy volunteers.

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