Diabetes insipidus, Lungenzysten und Abduzensparese

Summary Diabetes insipidus, lung cysts and abducens nerve palsy A 22-year-old smoker presenting with dry cough and diabetes insipidus reported a history of transient abducens nerve palsy 15 months previously. The results of chest x-rays and bronchoalveolar lavage prompted the diagnosis of Langerhans cell histiocytosis with involvement of the lung and posterior pituitary gland. Smoking cessation resulted in disappearance of the cough. Ten months later symptomatic hypogonadotropic hypogonadism developed, suggesting involvement of the anterior pituitary gland. The pathophysiology, diagnostic workup and treatment of Langerhans cell histiocytosis are briefly discussed.