Rehabilitation in progressive multiple sclerosis | Zendy

M. Haupts | Zendy; Dietmar Seidel | Zendy

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Rehabilitation in progressive multiple sclerosis

Author(s) -

M. Haupts,

Dietmar Seidel

Publication year - 2018

Publication title -

swiss archives of neurology psychiatry and psychotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.131

H-Index - 13

eISSN - 2297-7007

pISSN - 2297-6981

DOI - 10.4414/sanp.2018.00592

Subject(s) - multiple sclerosis , expanded disability status scale , rehabilitation , physical medicine and rehabilitation , physical therapy , medicine , occupational therapy , psychology , psychiatry

Progressive multiple sclerosis (PMS) affects probably half of multiple sclerosis patients worldwide. Both secondary PMS and primary PMS typically start after the age of 40 years [1], and are subsumed under PMS in recent criteria (either “active” or “non-active”) [2]. The pathological bases of axonal loss and tissue atrophy may include diffuse or focal inflammation in meninges and parenchyma, mitochondrial deficiencies, oligodendrocyte dysfunction and microvascular changes [3]. Most in-vivo research is based on brain imaging data: magnetic resonance imaging (MRI) demonstrates brain atrophy. Spinal cord and gray matter atrophy are typical features of PMS. Optical coherence tomography shows retinal layer atrophy, which correlates with neurodegeneration [4].

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