Primary Neuroendocrine Tumor of the Prostate with Bone Metastasis

Primary neuroendocrine tumors of the prostate are very rare and their biologic behaviour is not yet well described. A case of primary, prostatic, neuroendocrine tumor with bone metastasis is described. A 50-year-old man presented with a 6months history of frequent urination, difficulty in urination and failure to empty the bladder. Transurethral prostate resection was performed and the pathological examination of the prostate tissue revealed a poorly-differentiated neuroendocrine carcinoma. Meanwhile, cervical magnetic resonance imaging that was planned due to the presence of neck pain revealed a mass lesion in the right paravertebral soft tissue and a pathological compression fracture of the C6 vertebral body. The patient underwent an operation in which C6 corpectomy, placement of homogenous bone graft and obtaining a biopsy specimen were performed. The pathological assessment of the biopsy revealed metastasis of a poorly-differentiated neuroendocrine carcinoma confirming the bone metastasis of the primary neuroendocrine tumor of the prostate