Analysis of Vitamin D Receptor (VDR) Gene Polymorphisms in Alopecia Areata

Aim: Alopecia areata (AA) is a disease characterized with hair loss on the hair skin any region of the body. This disease affects approximately 1%u20132% of the general population. The etiopathogenesis of this disease is unclear but infections, genetic, psychological and autoimmune factors is known play to role. Vitamin D is thought to be a regulator of the immune system and the action of it is dependent on the vitamin D receptor (VDR). Given the autoimmune component shared by this autoimmune diseases. In this study investigated the role of VDR gene polymorphisms in the development of AA. Material and Method: The study group included 198 patients with AA and 167 control. Genomic DNA was extracted from blood samples using DNA isolation kit. The frequency of VDR gene polymorphisms genotypes and allelic variants were analyzed by using Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphisms (RFLP) method. Results: Statistical evaluation of data results showed a not significant association for genotypic frequency distribution between the VDR gene BsmI (rs1544410) and ApaI (rs7975232), TaqI (rs731236) polymorphisms and AA (p=0.8891, 0.7309, 0.6761, respectively). Discussion: Our study reflects that VDR gene polymorphisms could not play a role in determining genetic susceptibility to AA