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Aim: In our study, we aim to investigate the demographic, clinic features and the treatments of patients with moderate to severe psoriasis who were followed in outpatient clinic of psoriasis of Department of Dermatology in Istanbul Medical School of Istanbul University. Material and Method: One thousand eight hundred and thirty-one patients, who were followed between 2002-2008 in outpatient clinic of psoriasis, were screened and 626 (34%) of them, who were moderate and severe, were evaluated retrospectively. Results: Three hundred five of the patients who participated in our study were female and 321 were male. Mean age of onset was 28.1. Most frequently clinical type was plaque psoriasis. Most frequently nail involvement was pitting in patients. Nail involvement was statistically common in arthropathic patients. Family history was statistically common in psoriasis patients with early onset. Retinoid was the most common used systemic drug. Narrow band UVB was the most common used phototherapy. Discussion: Moderate to severe psoriasis rate was 34%. Female to male ratio was close to one another. Peak age of onset of psoriasis was between 16-25 years old. The most common concomitant systemic disease was diabetes mellitus. The findings were consistent with the literature. Consequently psoriasis is a chronic, recurrent, inflammatory dermatologic disease which affect 2% of the word and which negatively affect the quality of life in patients with comorbidities. Especially in severe forms of psoriasis can cause loss of labor in patients. A good knowledge of demographic and clinical characteristics of psoriasis is important to shedding light on the further clinical studies

Clinical and Demographic Characteristics of 626 Patients with Moderate and Severe Psoriasis