Synthesis and Medicinal Evaluation of Mannich Bases Carrying Azetidinone Moiety | Zendy

Aluru Guru Prasad | Zendy; Kakarlapudi Ranga Raju | Zendy; A. Raghavendra Guru Prasad | Zendy; B. Santosh Kumar | Zendy; Lakshmana Rao Krishna Rao Ravindranath | Zendy

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Synthesis and Medicinal Evaluation of Mannich Bases Carrying Azetidinone Moiety

Author(s) -

Aluru Guru Prasad,

Kakarlapudi Ranga Raju,

A. Raghavendra Guru Prasad,

B. Santosh Kumar,

Lakshmana Rao Krishna Rao Ravindranath

Publication year - 2014

Publication title -

the annals of clinical and analytical medicine

Language(s) - English

Resource type - Journals

ISSN - 2667-663X

DOI - 10.4328/jcam.2408

Subject(s) - moiety , medicine , mannich reaction , traditional medicine , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , chemistry

Aim: To synthesize, characterize and in vitro screen for antibacterial, antifungal and anthelmintic activity of series of Mannich bases carrying azetidinone moiety. Material and Method: The compounds were characterized by IR, 1H NMR and mass spectra and by elemental analysis. Their antimicrobial activity against the selected microorganism was found out by disk diffusion method. Anthelmintic activity studies were performed on Pheretima posthuma. Results: The antibacterial activity of the title compounds was compared with that of ciprofloxacin, antifungal activity with clotrimazole and anthelmintic activity was compared with that of piperazine citrate. Discussion: All the compounds showed significant antimicrobial activity in particular, the activity of compounds 7c, 7e, 7f and 7h was comparable to that of standard antibiotics employed in the studies. Further, the compound 7h with N-methylpiperazine substituent showed anthelmintic activity comparable to that of the standard drug

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