The Effect of Erythropoietin on Sodium During Ischemia Reperfusion Injury in Rats

Aim: of this experiment study was the erythropoietin testing, on rat model and particularly on ischemia reperfusion protocol. The beneficial or the non effect of that molecule was studied biochemically on blood sodium. Material and Method: used were 40 rats of mean weight 247.7 gr. Sodium was measured on these time points: on 60 min after reperfusion (groups A and C), and on 120 min after reperfusion (groups B and D), A and B without but C and D with erythropoietin administration. Results: were that 1) erythropoietin administration increased non significantly the sodium by 0.3 mmol/l [-1.43338 mmol/l - 2.03338 mmol/l] (P= 0.7280), in accordance also with paired t-test (P= 0.6992), 2) reperfusion time decreased non significantly the sodium by 1.1 mmol/l [-2.798181 mmol/l - 0.598181 mmol/l] (P= 0.1976), in accordance also with paired t-test (P= 0.1625), and 3) interaction of erythropoietin administration and reperfusion time decreased non significantly the sodium levels by 0.1636364 mmol/l [-1.209211 mmol/l - 0.8819382 mmol/l] (P= 0.7531). Discussion: Erythropoietin administration as well its interaction with reperfusion time have miscellaneous non significant short %u2013 term effects on sodium on the narrow context of 2 hours. Perhaps, a longer study time may reveal clearer and more significant effects