The Efect of Helicobacter Pylori Eradication on Atrophic Gastritis and Intestinal metaplasia

 Aim: The aim of this prospective study was to evaluate whether helicobacter pylori eradication could improve gastric atropy or intestinal metaplasia. Material and Method: Forty-two pylori infected patients were evaluated for the status of atrophic gastritis and intestinal metaplasia. Two biopsy specimens from antrum and two biopsy specimens from corpus were taken before and 6 months after the helicobacter pylori eradication therapy. Helicobacter pylori status was determined by C-urea breath test 2 and 6 months after for helicobacter pylori eradication. Severity of gastric atrophy and intestinal metaplasia was classified as mild, moderate or severe according to the updated Sydney classification. Results: The scoring of gastric atrophy was found significantly decreased in helicobacter pylori eradicated group after 6 months, while no significant change was found in H. pylori non-eradicated group. Intestinal metaplasia wasn’t recorded as improved in neither helicobacter pylori eradicated group nor helicobacter pylori noneradicated  group. Conclusion; It can be suggested that reversal of atrophy and intestinal metaplasia may occur even after several years, so the positive effectof eradication therapy might have been even better with a longer follow-up period. The results reported here are those obtained during the 6 months period