Does Bolus Isotonic Saline Infusion Prevents Ratsfrom Contrast Induced-Nephropathy?

Aim: Contrast-induced nephropathy (CIN) is defined as acute impairment in renal functions following the use of contrast agents. We aimed to search the effect of “IV bolus infusion of isotonic sodium cloride” on the development of CIN in an experimental rats model. Material and Method: In our study, 28 Wistar albino female rats were seperated into four groups with seven rats in each. Groups were defined as: Neither contrast agent nor fluid was given (group 1), only contrast agent (Group II), initial contrast agent and then IV fluid (Group III) and initial IV fluid and then contrast agent (Group IV). Blood samples for serum creatinin (Cr) values were obtained twice as at the baseline and then 72 hours later. In serum creatinin levels,  more than 25% increases after 72-hour’s levels according to basal values were accepted as CIN. Results: In our study, no rat had died during the study period. CIN was developed in four rats in the Group II and in one rat in the Group IV. When comparing the mean values of serum Cr; there was no significant difference between the Group I and the Group IV while there was a significant difference between the Group II and the Group III. When comparing the serum creatinine levels between all groups after 72 hours, serum creatinine levels were significantly lower than the other. Discussion: Our animal study results showed that bolus isotonic fluid infusion either before contrast agent or after contrast agent is effective to decrease CIN development