Effect of topical application of melatonin on serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a) in patients with type 1 or type 2 diabetes and periodontal disease | Zendy

Antonio Cutando | Zendy; Javier Montero | Zendy; Rafael Gómez-de Diego | Zendy; MJ Ferrera | Zendy; Antonio LópezValverde | Zendy

Open Access

Effect of topical application of melatonin on serum levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a) in patients with type 1 or type 2 diabetes and periodontal disease

Author(s) -

Antonio Cutando,

Javier Montero,

Rafael Gómez-de Diego,

MJ Ferrera,

Antonio LópezValverde

Publication year - 2015

Publication title -

journal of clinical and experimental dentistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.481

H-Index - 23

ISSN - 1989-5488

DOI - 10.4317/jced.52604

Subject(s) - medicine , melatonin , diabetes mellitus , tumor necrosis factor alpha , nephelometry , c reactive protein , placebo , endocrinology , type 2 diabetes , interleukin , gastroenterology , interleukin 6 , immunology , inflammation , cytokine , pathology , antibody , alternative medicine

The present clinical trial study was designed to assess the effect of topical application of melatonin on serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) in patients with diabetes and periodontal disease in comparison with healthy controls.

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