Evidence for Enhanced Intestinal Absorption of Digoxin by P-Glycoprotein Inhibitors | Zendy

Hadi Valizadeh | Zendy; M Mehtari | Zendy; Parvin ZakeriMilani | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Evidence for Enhanced Intestinal Absorption of Digoxin by P-Glycoprotein Inhibitors

Author(s) -

Hadi Valizadeh,

M Mehtari,

Parvin ZakeriMilani

Publication year - 2013

Publication title -

tropical journal of pharmaceutical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.209

H-Index - 36

eISSN - 1596-5996

pISSN - 1596-9827

DOI - 10.4314/tjpr.v11i6.10

Subject(s) - digoxin , chemistry , erythromycin , p glycoprotein , pharmacology , efflux , chromatography , intestinal permeability , clarithromycin , medicine , antibiotics , biochemistry , heart failure , multiple drug resistance

Purpose: To investigate the influence of macrolides as P-glycoprotein inhibitors on the level of intestinal absorption of digoxin. Methods: Jejunal segments of anaesthetized rats were cannulated and perfused by digoxin in phosphate buffered saline (PBS) at 37 °C in the presence or absence of macrolides (erythromycin and clarithromycin). Samples were obtained from outlet tubing at different time points and digoxin concentration assayed. The effective permeability of the drug was calculated after analyzing the samples using reverse-phase HPLC method. Results: Digoxin effective permeability was in the range of 0.24 ± 0.02 ×10 -4 to 0.32 ± 0.06 ×10 -4 cm/sec for the control group. The macrolides significantly (p 0.05) was observed between the effects of the two macrolides. Conclusion: The probable explanation for digoxin-macrolide interaction is inhibition of intestinal Pglycoprotein-mediated efflux of digoxin which leads to increased digoxin intestinal absorption.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research