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Background : Medicinal plants are valued as sources of natural compounds some of which are effective against several infectious diseases. Plants from the genus Combretum have been used traditionally in various African societies to treat variety of medical problems especially infectious diseases. Objective : In this study, we investigated the antibacterial activity of the methanol extracts from the leaves of three Combretum species namely Combretum hispidum, Combretum racemosum and Combretum platypterum against seven strains of methicillin resistant Staphylococcus aureus (MRSA) in vitro. Materials and methods : Methanol extract from bjected to agar diffusion assay and broth micro-dilution Combretum hispidum, Combretum racemosum and Combretum platypterum were subjected test for the determination of antibacterial activity and minimum inhibitory concentration (MIC), all the extracts were tested against eight different strain of MRSA. Imipenem and ciprofloxacin were used as control. Results : Extract from Combretum racemosum leaves showed significant anti-MRSA activity with zone of inhibition as high as 37 mm and MIC values ranging from 0.16 - 1.25 mg/mL on all tested strains of MRSA. Extracts from the two other species did not exhibit any activity on all tested strain. Conclusion : Methanol extract from C. racemosum is highly effective against MRSA and it could be a potential source of newer antimicrobial agent against MRSA infections Keywords : Combretum species, Methicillin resistance Staphylococcus aureus , Anti-bacteria

nigerian journal of pharmaceutical research

In-vitro antibacterial screening of methanol extracts of three combretum species against seven strains of Methicillin Resistant Staphylococcus aureus (MRSA)