Synthesis of some 1,2,5-trisubstituted benzimidazole analogs as possible anthelmintic and antimicrobial agents | Zendy

Rajiv Dahiya | Zendy; Rajwinder Kaur | Zendy

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Synthesis of some 1,2,5-trisubstituted benzimidazole analogs as possible anthelmintic and antimicrobial agents

Author(s) -

Rajiv Dahiya,

Rajwinder Kaur

Publication year - 2008

Publication title -

international journal of biological and chemical sciences

Language(s) - English

Resource type - Journals

eISSN - 1997-342X

pISSN - 1991-8631

DOI - 10.4314/ijbcs.v2i1.39718

Subject(s) - benzimidazole , antimicrobial , anthelmintic , chemistry , candida albicans , bacteria , acetic acid , triethylamine , biological activity , stereochemistry , combinatorial chemistry , organic chemistry , biology , biochemistry , microbiology and biotechnology , in vitro , ecology , genetics

A novel series of 1,2,5-trisubstituted benzimidazole derivatives was synthesized by coupling 2-mercapto-5-methoxybenzimidazol-1-acetic acid with several amino acid methyl ester hydrochlorides/dipeptides/tripeptides using dicyclohexylcarbodiimide (DCC) as the coupling agent and triethylamine (TEA) as the base. All newly synthesized compounds were characterized by spectral as well as elemental analysis and evaluated for their biological potential. Compounds 5, 8 and 12 were found to exhibit potent anthelmintic activity against M. konkanensis, P. corethruses and Eudrilus sp. in comparison to standard drug - mebendazole. Moreover, compounds 7, 9 and 13 possessed potent antifungal activity against C. albicans and compounds 4 and 10 displayed good activity against pathogenic bacteria P. aeruginosa. Gram negative bacteria were found to be more sensitive in comparison to gram positive bacteria towards the newly synthesized benzimidazolopeptide analogs. Keywords : Benzimidazolopeptides, Amino acids, Coupling, Pharmacological activities, Dermatophytes International Journal of Biological and Chemical Sciences Vol. 2 (1) 2008 pp. 1-13

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