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L’infertilite est un probleme de sante publique dans les pays en voie de developpement et son exploration onereuse chez l’homme repose surtout sur la cytologie du sperme, sans l’associer a la biochimie du sperme. Ainsi une relation entre les anomalies du spermogramme et l’alpha-glucosidase, le fructose et le citrate du plasma seminal, a ete rechercher, afin de justifier ou non la rarete de la biochimie du sperme. Une etude transversale et descriptive, s’est deroulee d’octobre 2017 a mars 2018 inclus, au laboratoire National de Sante Publique de Libreville. Tous les patients admis consecutivement pendant la periode d’etude, pour effectuer un spermogramme pour bilan d’infertilite, ont ete inclus. Le sperme, obtenu au laboratoire par masturbation, a servi aux analyses macroscopiques et microscopiques. L’alpha-glucosidase neutre, le fructose et le citrate ont ete doses dans le plasma seminal. L’analyse univariee a permis de choisir les parametres a inclure dans l’analyse factorielle des correspondances entre les parametres cytologiques et biochimiques. Sur le plan du spermogramme, les anomalies retrouvees etaient nombreuses et associees chez un meme malade, eu egard a l’indice d’anomalies multiples. L’anomalie cytologique predominante etait l’oligoasthenoteratonecrozoospermie (40,0%), suivie de l’oligoasthenoteratospermie (7,3%). Sur le plan biochimique, l’apha-glucosidase etait basse chez 21,8% des patients, alors que le citrate etait abaisse chez 20,0% des sujets. Seuls 1,8% des sujets presentaient une baisse du taux de fructose. Par ailleurs, les anomalies biochimiques n’etaient pas associees aux anomalies du spermogramme. Le profil cytologique du spermogramme de cette population est domine par les associations d’anomalies. Cependant, comme ces parametres ne sont pas associes aux parametres biochimiques du plasma seminal, il est indispensable de prescrire ces deux types d’analyses pour une meilleure prise en charge des sujets consultant pour infertilite. © 2018 International Formulae Group. All rights reserved. Mots cles: spermogramme, infertilite, fructose, citrate, alpha-glucosidase English Abstract Infertility is a public health problem in developing countries and its expensive exploration in male relies mainly on the cytology of sperm, without association with seminal biochemistry. Thus, a relationship between spermogram abnormalities and alpha-glucosidase, fructose and seminal plasma citrate has been investigated, in order to justify or not the rarity of sperm biochemistry. A cross-sectional and descriptive study  was conducted from October 2017 to March 2018, at the Libreville National Public Health Laboratory. All patients admitted consecutively during the study period, to perform a spermogram for infertility assessment, were included. Sperm, obtained in the laboratory by masturbation, was used for macroscopic and microscopic analyzes. Neutral alpha-glucosidase, fructose and citrate were obtained in seminal plasma. Univariate analysis made it possible to choose the parameters to be included in the factorial analysis between cytological and biochemical parameters. In terms of spermogram, abnormalities found were numerous and associated in the same patient, given the multiple anomalies index. The predominant cytologic abnormality was oligoasthenoterato-necrozoospermia (40.0%), followed by oligoasthenoteratospermia (7.3%). For biochemical tests, apha-glucosidase was low in 21.8% of patients, while citrate was lowered in 20.0% of subjects. Only 1.8% of subjects had a decrease in fructose levels. In addition, biochemical abnormalities were not associated with abnormalities of the spermogram. Associations of anomalies dominate the cytological profile of the spermogram of this population. However, as these parameters are not associated with the biochemical parameters of the seminal plasma, it is essential to prescribe these two types of analysis for a better support of the subjects consulting for infertility. © 2018 International Formulae Group. All rights reserved. Keywords: Spermogram, infertility, fructose, citrate, alpha-glucosidase

international journal of biological and chemical sciences

Analyse des paramètres du spermogramme en relation avec le fructose, le citrate et l’alpha glucosidase neutre du sperme chez les hommes consultant pour infertilité à Libreville