Mutations of rpob Gene Associated with Rifampin Resistance among Mycobacterium Tuberculosis Isolated in Tuberculosis Regional Reference Laboratory in Northeast of Iran during 2015-2016 | Zendy

Ashraf Tavanaee Sani | Zendy; Habib Ashna | Zendy; Afsaneh Kaffash | Zendy; Azad Khaledi | Zendy; Kiarash Ghazvini | Zendy

Open Access

Mutations of <i>rpob</i> Gene Associated with Rifampin Resistance among<i> Mycobacterium Tuberculosis</i> Isolated in Tuberculosis Regional Reference Laboratory in Northeast of Iran during 2015-2016

Author(s) -

Ashraf Tavanaee Sani,

Habib Ashna,

Afsaneh Kaffash,

Azad Khaledi,

Kiarash Ghazvini

Publication year - 2018

Publication title -

ethiopian journal of health sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.479

H-Index - 20

eISSN - 2413-7170

pISSN - 1029-1857

DOI - 10.4314/ejhs.v28i3.7

Subject(s) - rpob , mycobacterium tuberculosis , tuberculosis , gene , virology , medicine , biology , microbiology and biotechnology , genetics , pathology

Drug resistance is a leading concern in control of TB. Resistance against rifampin as one of the most important drugs in the treatment of Mycobacterium tuberculosis is caused by mutations in the 81-base pair region of the rpoB gene encoding the β-subunit of RNA polymerase. This study aimed to characterize the mutations in the rpoB gene associated with rifampin resistance among M. tuberculosis.

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