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Background:   Treponema pallidum  and Hepatitis B virus (HBV) infections are endemic in developing countries and poses public health problem among HIV/AIDS adult patients. Co-infection of these pathogens might influence the outcome of HIV/AIDS and in addition  T.pallidum  infection significantly increases the risk of contracting HIV infection. This study aimed at determining the prevalence of these pathogens among HIV/AIDS adult patients attending Nyamagana district and Sekou Toure regional hospitals in Mwanza city.   Methods:  A cross-sectional hospital based study involved 130 HIV/AIDS adult patients attending care and treatment clinic at Sekou Toure regional hospital and Nyamagana district hospital was done between June and July 2014.  T.pallidum  and hepatitis B surface antigen (HBsAg) were detected using commercially available immunochromatographic rapid tests.   Results:  Of the 130 HIV/AIDS adult patients, 9/130 (6.9%) had hepatitis B surface antigen positive test while 18(13.85%) were positive for syphilis. Co infection of  T.pallidum  and hepatitis B virus occurred in 2/130 (1.5%) of participants. There were no any factors that significantly associated with positive hepatitis B surface antigen while multiple sexual partners and history of sexually transmitted diseases were significantly associated with positive syphilis test (P= 0.023 and 0.001 respectively).   Conclusions and recommendations:  In this setting co infection of Hepatitis B virus and  T.pallidum  is low. However, individual infections are high necessitating routine screening of these pathogens among HIV/AIDS patients so that appropriate treatment can be initiated.   Keywords:   Treponema pallidum , Hepatitis B Virus, HIV/AIDS, Co infection

Treponema pallidum and Hepatitis B virus co-infection among HIV infected patients in Mwanza city