Haematological Indices, Blood glucose levels and lipid profile of rats administered Tartrazine E102 | Zendy

KE Imafidon | Zendy; S Wuruyai | Zendy; S Odudu | Zendy; S Ighodalo | Zendy; SO Atewe | Zendy; IJ Akuneatiwu | Zendy; BI Egede | Zendy

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Haematological Indices, Blood glucose levels and lipid profile of rats administered Tartrazine E102

Author(s) -

KE Imafidon,

S Wuruyai,

S Odudu,

S Ighodalo,

SO Atewe,

IJ Akuneatiwu,

BI Egede

Publication year - 2016

Publication title -

archives of medical and biomedical research

Language(s) - English

Resource type - Journals

eISSN - 1694-2086

pISSN - 1694-2078

DOI - 10.4314/ambr.v2i4.4

Subject(s) - tartrazine , body weight , endocrinology , cholesterol , total cholesterol , lipid profile , medicine , chemistry , biochemistry

This work was done as a part of safety assessment to determine the effects of Tartrazine E102 on some haematological indices, glucose levels and blood lipid profile in rats. An animal model was used as a basis for interpreting the situation in humans. Consequently, 40 albino rats were divided into 5 groups of 8 rats each. All the animals were fed rats’ mash and water and administered 0, 10, 20, 40 and 80mg/kg body weight of Tartrazine E102 respectively. Weekly measurements of body weight were recorded. Results obtained showed a significant reduction in body weight gain and blood glucose levels compared with the control. A non-dose dependent effect was observed on total cholesterol, LDL cholesterol, total white blood cells and monocytes. A slight but significant increase was observed in haematocrit at the highest dose levels. Conclusively, Tartrazine E102 exhibited a hypoglycemic effect in rats, no negative effect was observed on lipid profile. KEY WORDS : Tartrazine E102; glucose; haematological; cholesterol; triacylglycerol

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