Pachybasin, a Major Metabolite from Culture Broth of Endophytic Coelomyceteous AFKR-18 Fungus isolated from a Yellow Moonsheed Plant, Arcangelisia flava (L.) Merr. | Zendy

Dewi Wulansari | Zendy; Yuliasri Jamal | Zendy; Praptiwi Praptiwi | Zendy; Andria Agusta | Zendy

Open Access

Pachybasin, a Major Metabolite from Culture Broth of Endophytic Coelomyceteous AFKR-18 Fungus isolated from a Yellow Moonsheed Plant, Arcangelisia flava (L.) Merr.

Author(s) -

Dewi Wulansari,

Yuliasri Jamal,

Praptiwi Praptiwi,

Andria Agusta

Publication year - 2014

Publication title -

hayati journal of biosciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.305

H-Index - 17

eISSN - 2086-4094

pISSN - 1978-3019

DOI - 10.4308/hjb.21.2.95

Subject(s) - plant use of endophytic fungi in defense , biology , secondary metabolite , fungus , candida albicans , antimicrobial , botany , antibacterial activity , metabolite , corpus albicans , microbiology and biotechnology , bacteria , biochemistry , genetics , gene

Endophytic fungi have been known to produce a broad range of biologically active secondary metabolites. One endophytic filamentous fungus, Coelomycetes AFKR-18, isolated from the young stems of a yellow moonsheed plant, Arcangelisia flava, has been found to produce pachybasin when placed in a liquid medium. The chemical structure of pachybasin was deduced from MS, 1D-, 2D-NMR spectrum analysis, and from reference data. On a micro-dilution test, pachybasin showed antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively

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