Gestational Age-Dependent Interplay between Endocannabinoid Receptors and Alcohol in Fetal Cerebral Arteries | Zendy

Maria N. Simakova | Zendy; Ana Tobiasz | Zendy; Ryan D. Sullivan | Zendy; Shivantika Bisen | Zendy; Jose R. Duncan | Zendy; J P Sullivan | Zendy; Steven P. Davison | Zendy; Danielle Tate | Zendy; Stacey Barnett | Zendy; Giancarlo Mari | Zendy; Alex M. Dopico | Zendy; An. Bukiya | Zendy

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Gestational Age-Dependent Interplay between Endocannabinoid Receptors and Alcohol in Fetal Cerebral Arteries

Author(s) -

Maria N. Simakova,

Ana Tobiasz,

Ryan D. Sullivan,

Shivantika Bisen,

Jose R. Duncan,

J P Sullivan,

Steven P. Davison,

Danielle Tate,

Stacey Barnett,

Giancarlo Mari,

Alex M. Dopico,

An. Bukiya

Publication year - 2018

Publication title -

journal of drug and alcohol research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.282

H-Index - 7

eISSN - 2090-8334

pISSN - 2090-8342

DOI - 10.4303/jdar/236068

Subject(s) - fetus , cerebral arteries , fetal alcohol syndrome , medicine , pregnancy , gestation , ethanol , alcohol , endocrinology , middle cerebral artery , anesthesia , physiology , biology , biochemistry , ischemia , genetics

Alcohol (ethanol) is one of the most widely consumed drugs. Alcohol consumption by pregnant women may result in a range of fetal abnormalities termed fetal alcohol spectrum disorders (FASDs). The cerebrovascular system is emerging as a critical target of alcohol in the developing brain. We recently showed that three episodes of prenatal alcohol exposure resulting in 80 mg/dL alcohol in maternal blood during mid-pregnancy up-regulated anandamide-induced dilation of fetal cerebral arteries. Moreover, ethanol dilated fetal cerebral arteries via cannabinoid (CB) receptors. Whether a critical role of fetal cerebral artery CB system in responses to alcohol was maintained throughout the gestation, remains unknow.

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